rivastigmine

基本解釋

Rivastigmine, a sort of acetylcholinesterase inhibitor, is used in the symptomatic treatment of mild to moderate Alzheimer's Disease (AD).
酒石酸卡巴拉汀是一種乙酰膽堿酯酶抑制劑,用于治療中、輕度老年癡呆癥(即阿爾茨海默氏癥:AD),目前已在瑞士上市,市場前景看好。
In this essa y, we have studied a synthesis routine of Rivastigmine, which is suitable of dom estic production.We prepared the racemic and gained (S)-isomer by the resoluti on with D-DTTA.
該文研究了一條適合國內(nèi)生產(chǎn)的合成路線，先合成外消旋體，再和D-酒石酸衍生物形成非對映體鹽，通過分級結晶進行分離，獲得S-異構體。
Keywords rivastigmine hydrogen tartrate;acetylcholine esterase（AchE） inhibitor;Alzheimer s disease;synthesis;
重酒石酸利斯的明;乙酰膽堿酯酶抑制劑;阿爾茨海默病;合成;
Keywords chromatography;high pressure liquid;rivastigmine;cholinesterase-inhibitors;dissolution;
色譜法;高壓液相;利斯的明;膽堿脂酶抑制劑;溶出度;
Keywords High performance liquid chromatography;enantioseparation;vancomycin;chiral stationary phase;rivastigmine;
高效液相色譜法;對映體拆分;手性固定相;卡巴拉汀;